Fucose (L-Fucose)
Introduction
Fucose is a functional ingredient from brown algae.
Many biomaterials use seaweeds as raw materials but none of them have been developed as functional
health foods because high purity refining technology has not been developed. However, we succeeded
in producing fucose with 99.9% purity through SMB (simulated moving bed) which is a method of continuous
chromatography.
Fucose is mainly known for anti-blood coagulation therapy. It also has function of increasing microbiome
activity in gut, inhibiting allergic reactions and anti-viral & anti-cancer functions. These show similar
tendencies in fucoidan but fucoidan has difficult in intestinal absorption as it’s a polymer.
Therefore the study of fucoidan as low-molecule compound is actively carried on lately.
Dyne Bio Inc. has manufactured monosaccharide complex including fucose and is in the process of
verifying its functionality in improving metabolic disease and enhancing joint health.
We are developing it as an ingredient of functional health food.
Structure of Fucose

Biological efficacy
Efficacy | Biological activity |
---|---|
Metabolic Syndrome- Obesity- Fatty liver |
• Anti-obesity- Reduction of the adipocytes differentiation - Inhibition of the expression of lipogenesis-related genes - Upregulation of lipolysis related gene expression - Reduction of fat accumulation in liver |
Immune function |
• Macrophage- cytokine expression(IL-6, GM-CSF) - Reduction of LPS-induced cytokine release (IL-6, TNF-α) in both of pretreatment and post-treatment of fucose |