①Dyne Intestinal-Liver System is an organ on a chip which replicates the human body’s intestine
and liver
②The three-dimensional intestinal cell culture was developed by applying a villi-like
construction. It shows the absorption of the intestine similar to that of the human body.
③This system is a type of micro-channel with a constant flow. This flow can spread the
substance and oxygen evenly to cells and culture medium.
※This flow is maintained through the gravity flow machine by setting the slope, the rate, and
the time that has stopped after the inclination to a computer program.
Features of 3-D HuChip® Dyne Intestinal-Liver System
Simulating blood flow allows more accurate view of the drug's effectiveness.
With the application of a villi-like construction, the intestine absorption pattern can be observed.
Continuous movement allows to keep cell viability high.
Layer isolation culture using membrane enables monitoring of the drug movement from intestine to liver.
Possible to observe the reaction of cells by injecting directly from blood vessel to liver.
Application
Identify pharmacokinetics and pharmacodynamics (PK/PD)
Identify the inhibition of fat accumulation in the liver
Identify the anti-diabetic effects (identify a-glucosidase, glucose transporter expression)
