Pioneer of Biotechnology

Creative technology and passion for change and progress


Microbial Enzymes



Dyne Bio Inc. has developed a new food processing enzyme, β-agarase, from Streptomyces coelicolor which is soil microorganism.

In general, Streptomyces coelicolor is an actinomyces which forms a colony and is structurally similar to fungi. Actinomycetes are well known for industrial strains producing industrial enzymes and antibiotics, etc.

However, we succeeded in producing β-agarase and it has been approved for new food additive by Ministry of Food and Drug Safety (MFDS) in Rep. of Korea. We developed new manufacturing process of neoagaro-oligosaccharides (Dyne-NAO), a new bioactive compound, by hydrolyzing the specific binding of agar using microbial enzyme β-agarase.



β-agarase : New Food Additive approved by Ministry of Food and Drug Safety in Rep. of Korea (Registration No.: 201833248; Reg. Date: 01.Nov.2018)


  • Safety evaluation of β-agarase preparations from Streptomyces coelicolor A3(2). Regulatory Toxicology and Pharmacology. 101, 142-155, 2019.
  • Non-targeted metabolomics unravels a media-dependent prodiginines production pathway in Streptomyces coelicolor A3(2). PLoS ONE. 13(11): e0207541, 2018.